Alto Neuroscience Reports Topline Results From A Phase 2b Trial Evaluating ALTO-100 As A Treatment For Major Depressive Disorder; Says Treatment With ALTO-100 Did Not Demonstrate Improvement In Depressive Symptoms Compared To Placebo In Patients With A Memory-based Cognitive Biomarker
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Alto Neuroscience announced that its Phase 2b trial for ALTO-100, a treatment for major depressive disorder, did not meet its primary endpoint of improving depressive symptoms compared to a placebo. However, ALTO-100 showed a favorable safety profile. Despite the trial results, Alto maintains a strong cash position to support future operations.

October 22, 2024 | 8:31 pm
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Alto Neuroscience's Phase 2b trial for ALTO-100 failed to show improvement in depressive symptoms compared to placebo, impacting the stock negatively. However, the drug's safety profile remains favorable, and the company is financially stable for future projects.
The failure to meet the primary endpoint in a Phase 2b trial is a significant setback for a biopharmaceutical company, likely leading to a negative short-term impact on the stock price. However, the favorable safety profile and strong cash position may mitigate some investor concerns.
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