The trading halt of Annovis Bio's shares is a direct result of a significant drop in stock price, which is typically a negative signal to investors and can lead to increased selling pressure once trading resumes. The 25.6% drop is substantial, indicating a strong negative market reaction to recent developments or news related to the company. This situation is likely to have a short-term negative impact on the stock's price as investor confidence may be shaken, and it could take time for the stock to recover.