The downgrade of Synovus Financial Corp. by a reputable analyst firm like Keefe, Bruyette & Woods, coupled with a significant reduction in the price target, is likely to negatively impact investor sentiment and the stock's short-term price movement. Analyst ratings and price targets are critical factors that investors consider when making investment decisions, and a downgrade with a lower price target usually leads to a decrease in stock price as it reflects a less optimistic outlook on the company's future performance.