The significant miss in EPS expectations for Despegar.com is likely to negatively impact investor sentiment in the short term, especially given the -147% deviation from expected earnings. However, the increase in revenue indicates some underlying business strength, which might mitigate the negative impact to some extent. Historical data shows that despite past earnings misses, the immediate impact on DESP's share price was minimal. This suggests that while the earnings miss is significant, the market's reaction may be tempered by other factors, including past performance and revenue growth.