The downgrade by a prominent analyst like Salveen Richter from Goldman Sachs from Buy to Neutral, coupled with a drastic reduction in the price target, is a strong signal of a bearish outlook on uniQure. This is likely to influence investor sentiment negatively and could lead to a short-term decline in the stock price. The significant cut in the price target reflects lowered expectations for the company's future performance, which could deter potential investors.