Given IOVA's past performance, where stock price movements were closely tied to earnings outcomes and guidance, a positive report exceeding the -$0.43 EPS estimate and optimistic future guidance could lead to a short-term positive impact on the stock price. The historical data shows that the stock reacts to earnings reports, and with the stock currently up 134.59% over the last year, investor sentiment appears strong. However, the confidence in this prediction is not absolute due to the unpredictable nature of market reactions.