The downgrade from Buy to Neutral by a major analyst like Citigroup can have a mixed impact on Qualcomm's stock price. While the downgrade suggests a more cautious outlook, the set price target of $160 might still indicate a potential upside from the current trading price, depending on market conditions. Investors may interpret the downgrade as a signal to reassess Qualcomm's growth prospects, potentially leading to short-term price volatility.