Reneo Pharmaceuticals, Inc. (RPHM) shares rose by 13.6% to $1.59 after receiving an acquisition proposal from Concentra for $1.80 per share. Other stocks also showed significant movement in Wednesday's mid-day session, with notable gainers including First Wave BioPharma, Inc. (FWBI), Cingulate Inc. (CING), and Cytokinetics, Incorporated (CYTK), among others. Losers for the day included Hallmark Financial Services, Inc. (HALL), Baosheng Media Group Holdings Limited (BAOS), and Iovance Biotherapeutics, Inc. (IOVA).