The news of a planned submission for approval in Japan is a positive development for BioCardia, indicating progress in the international regulatory process. This could lead to an expansion of the company's market and potential revenue growth. The impact is scored as positive (1) due to the potential for future sales and market expansion. The relevance is set at 100 as the news is directly about BioCardia. The importance is at 75, considering that regulatory approval is a significant milestone for medical treatments, but the actual approval and subsequent sales are still uncertain. The confidence level is at 80, reflecting the clear timeline provided but acknowledging that regulatory processes can be unpredictable.