Korro Announces Selection Of Its First Development Candidate For The Potential Treatment Of Alpha-1 Antitrypsin Deficiency
Portfolio Pulse from Benzinga Newsdesk
Korro Bio, Inc. (KRRO) has nominated KRRO-110, its first RNA editing oligonucleotide candidate from its OPERA platform, for the treatment of Alpha-1 Antitrypsin Deficiency (AATD). KRRO-110 has shown promise in preclinical mouse models, demonstrating the ability to repair the A1AT protein misfolding and reduce liver aggregates. With over 50% editing efficiency and increased secretion of normal A1AT protein, Korro expects to make a regulatory filing in the second half of 2024. AATD is a genetic disorder with limited treatment options, and KRRO-110 could potentially transform the standard of care.
December 07, 2023 | 1:10 pm
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Korro Bio's nomination of KRRO-110 as a development candidate for AATD treatment, backed by positive preclinical data, could be a significant milestone for the company and AATD patients. The potential regulatory filing in 2024 indicates progress in their pipeline.
The announcement of KRRO-110 as a development candidate for AATD by Korro Bio is a critical step in the company's progress and could lead to increased investor interest. The positive preclinical results suggest potential for the candidate to meet an unmet medical need, which may positively influence the stock price in the short term. However, as the regulatory filing is not expected until the second half of 2024, the actual impact on revenues and the long-term success of the candidate will take time to materialize.
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