The reduction in workforce is a significant move that indicates TuSimple is likely undergoing financial strain or a strategic pivot. This could lead to short-term negative sentiment among investors, as layoffs often signal underlying issues within a company. However, the restructuring could also be seen as a cost-saving measure, which might be viewed positively in the longer term. In the short term, the impact is likely negative due to the immediate uncertainty and potential costs associated with the layoffs.