The average price target of $367.13 for Vertex Pharmaceuticals (VRTX) is higher than its current price of $323.24, indicating a potential upside. The increase in the average price target by 13.81% from the previous target also suggests a positive outlook for the stock. Analysts' opinions are generally considered reliable indicators of a stock's potential performance, and in this case, the mixed ratings and higher price target imply a positive short-term impact on VRTX's stock price.